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Imbalances in Mouth Microflora May Indicate Developing Rheumatoid Arthritis


Scientists report specific dissimilarities in mouth microbial compositions among patients with early rheumatoid arthritis (ERA) and those at risk of developing the disease, compared with healthy individuals who were not at risk.

The findings come from a study published in Arthritis & Rheumatology titled, “The oral microbiome in early rheumatoid arthritis patients and individuals at risk differs from healthy controls.”


Prevotella and Veillonella—both gram-negative anaerobes—were at higher relative abundance in saliva, and Veillonella was also at higher relative abundance in tongue coating, of both early rheumatoid arthritis patients and at-risk individuals compared to healthy controls,” the authors note. “Increased relative abundance of this potentially pro-inflammatory genus in ERA patients and at-risk individuals suggests a link between the oral microbiome and RA.”


The 50 participants in the study, all in their early 50s, include early rheumatoid arthritis (ERA) patients, at‐risk individuals with pain in their joints (arthralgia) or detectable autoantibodies, and healthy controls.


The authors led by Johanna Kroese, PhD, at the University of Amsterdam, conducted periodontal examinations scoring patients based on several periodontal variables including bleeding on probing (BOP), pocket probing depth (PPD), and periodontal inflamed surface area (PISA). Patients in the three groups show no differences in these scores.


The authors then conduct 16S rDNA amplicon sequencing to compare the microbial composition of subgingival dental plaque, saliva, and tongue coating. They find a difference in the microbial compositions of saliva and tongue coating between the ERA and at-risk groups, but no difference among the three groups in the microbial composition of dental plaque.


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